US Republican presidential candidate Donald Trump says his main Democratic rival, Hillary Clinton, is “playing the woman card left and right,” but American women do not like her.

“She is a woman, she is playing the woman card left and right,” Trump told CNN early Wednesday. “She’s playing it much harder this time and she will be called on it.”

“If she didn’t, she would be doing poorly,” added Trump, who swept all five of Tuesday's East Coast primaries.

Trump maintained his commanding lead on fellow Republicans Ted Cruz and John Kasich, gaining victory in the five states with Pennsylvania at 58 percent, Connecticut at 65 percent, Maryland at 61 percent, Delaware at 60 percent and Rhode Island 66 percent.

Talking to CNN on Wednesday, Trump touted decisive wins in five Atlantic states. “I won five states I won them very conclusively. Everyone’s saying that,” Trump said.

“We won tremendous victories, even larger than anticipated,” he added “We also signed a lot of delegates…others are to come.”

Clinton, meanwhile, scored victories in four Democratic primaries on Tuesday. She won Maryland (66 percent), Pennsylvania (57 percent), and Delaware (59 percent) and Connecticut (50.1 percent) while Vermont Democratic Senator Bernie Sanders won the Rhode Island vote (55 percent).

In his victory speech on Tuesday night, Trump said that Clinton, who could be the first woman to serve as president, wouldn't get 5 percent of the vote in a general election if she were a man.

"Frankly, if Hillary Clinton were a man, I don't think she'd get 5 percent of the vote," the Republican presidential front-runner told supporters gathered at Trump Tower in New York.

"The only thing she's got going is the woman's card," Trump added. "And the beautiful thing is that women don't like her. ... And look at how well I did with women tonight."

But according to a survey, Clinton is still much more popular than Trump among women.

About 43 percent of women have a favorable opinion of the former US secretary of state, compared to 54 percent with an unfavorable opinion, the Morning Consult poll showed.

On the other hand, Trump is viewed favorably by just 34 percent of women. In one previous poll, he scored even poorly. Gallup found that just 23 percent of women have a favorable opinion of the billionaire businessman. And, the majority of women simply don't like Trump.